Volume 1, Issue 3
Quantitative Structure–Activity Relationship Studies on Benzylideneaminoxy Propionic Acid Anti-Inflammatory Agents
Author(s): Ramalakshmi 1 and Arun Kumar 2*
1. C. L .Baid Metha College of Pharmacy, Thuraipakkam, Chennai, Tamil Nadu, India
2. College of Pharmacy, SRM University, Kattankulathur, Chennai, Tamil Nadu, India
Abstract: A series of lipooxygenase inhibitors were selected and subjected to QSAR analysis using silicon graphics work station and cerius 2 software. The physicochemical parameters generated were converted to mathematical equation using stepwise multiple equations. Then genetic function approximation is also performed. The statistical parameters were satisfactory. The results indicated that contributing parameters are Connolly surface, Radius of gyration and molecular refractivity.
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