Volume 1, Issue 3
Thermodynamics of the Formation of Trivalent Lanthanide Complexes Carrying Adenosine Drug in Mixed Solvent Media
Author(s): Shailendrasingh Thakur 1*, Sahebrao Naikwade 2 and Mazahar Farooqui 3
1. Dept. of Chemistry, Milliya Art’s Science and Management Science College, Beed (MS) 431122, India.
2. Principal, Mrs. K. S. K. Arts, Commerce and Science College, Beed ((MS) 431122, India.
3. Post Graduate and Research center, Maulana Azad College, Aurangabad (MS) 431003, India.
Abstract: The stability constant of Adenosine drug with trivalent lanthanide metal ions La3+, Ce3+, Nd3+, Sm3+, Gd3+, Tb3+ and Dy3+ using a pH metric titration technique in 20% (v/v) ethanol-water mixture at three different temperatures (25 °C, 35 °C and 45 °C) and at an ionic strength of 0.1M NaClO4 were studied. The method of Calvin and Bjerrum as adopted by Irving and Rossotti has been employed to determine metal-ligand stability constant (logK) values. The trend in the formation constants follows the order: La3+< Ce3+< Nd3+< Sm3+> Gd3+< Tb3+< Dy3+ and it shows a break at gadolinium. The thermodynamic parameters such as Gibb’s free energy change (∆G), entropy change (∆S) and enthalpy change (∆H) associated with the complexation reactions were also calculated. The formation of metal complexes was found to be spontaneous and exothermic in nature.
Related Graphics:
Fig 1: Adenosine
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