Volume 1, Issue 4
Synthesis and characterization of pyrimidine bearing 1, 3, 4-oxadiazole derivatives and their potential antifungal action
Author(s): Andrews B1*, Mansur Ahmed1
- Department PG & Research Department of Chemistry, Islamiah College, Vaniyambadi-635752, Affiliated to Thiruvalluvar University, Vellore, Tamilnadu, India.
Abstract: A series of pyrimidine bearing 1, 3, 4-oxadiazole derivatives have been synthesized and evaluated for antifungal activity. All the structures of the newly synthesized compounds have been supported by IR, 1H-NMR, 13C-NMR, GC-MS and CHN analysis. Most of the compounds have shown promising antifungal activity when compared with the standard drug amphotericin-B.
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5-(5-amino-1,3,4-oxadiazol-2-yl)-3,4-dihydro-6- methyl-4-phenylpyrimidin-2(1H )-one 3a.
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