Vol. 3, Issue 1 (2015)
Synthesis and antimicrobial evaluation of novel amino acids coupled piperidine hybrids
Author(s): Dr. Shivakumara Kanchidoddi Nanjaiah
Abstract: A range of new amino acids-4-benzylpiperidine conjugates 3(a-l) were successfully synthesized with high yield, by coupling of Boc-protected amino acids with 4-benzylpiperidine using EDCI and HOBt as coupling agents. The reaction took place in basic media (NMM) at a temperature of -150C for a duration of 24 hours. The synthesized compounds were thoroughly characterized using techniques such as 1HNMR, elemental analysis, Rf values, and recording melting point. Additionally, the antimicrobial activities of these compounds were assessed, revealing significant activities in some cases. The compounds were tested against antibacterial strains including Staphylococcus aureus, Escherichia coli, Klebsiella pnemoniae, and Pseudomonas aeruginosa, as well as antifungal strains such as Aspergillus Niger, Aspergillus flavus, and Fusarium monoliforme. Notably, compounds 3e, 3i, and 3j exhibited good to significant activities compared to the starting material, although they were less potent than conventional drugs. Consequently, these compounds hold promise as valuable tools for further research endeavours.
Pages: 48-53 | 12 Views 9 Downloads
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How to cite this article:
Dr. Shivakumara Kanchidoddi Nanjaiah. Synthesis and antimicrobial evaluation of novel amino acids coupled piperidine hybrids. Int J Chem Stud 2015;3(1):48-53.
