Vol. 7, Issue 1 (2019)
Impact of Prosopis cineraria (L.) Druce leaves on hematological parameters against induced sub-acute toxicity of Parthenium hysterophorus L. in wistar albino rats
Author(s): Anita Rathore, Rohitash Dadhich, Kamal Purohit, Shiv Kumar Sharma, Chandra Shekhar Vaishnava, Bincy Joseph and Anirudh Khatri
Abstract: An ameliorative effect of Prosopis cineraria leaves on hematological parameters against induced sub-acute toxicity of Parthenium hysterophorus L. in Wistar albino rats was studied. A total of eighty clinically healthy adult albino rats between 2 and 3 months of age of either sex were divided in eight experimental groups each comprising of ten rats. Parthenium toxicity was induced by oral feeding of ethanolic extract of Parthenium at 150, 300 and 450 mg/kg body weight in group II, III and IV respectively for 28 days. Group V, VI and VII were fed with ethanolic extract of Parthenium at 150, 300 and 450 mg/kg body along with 200 mg/kg body weight of methanolic extract of leaves of Prosopis cineraria. Group I serve as control while group VIII was kept as treatment control and fed only methanolic extract of leaves of Prosopis cineraria at 200 mg/kg body weight. The treated rats showed a significant (P≤0.05) increase in total leukocyte count, granulocytes percentage and platelet count receiving the different dose of parthenium which indicated a deleterious effect of parthenium on blood cells. Significant reduction of total erythrocyte count, hemoglobin, lymphocytes percentage, mean platelet volume, packed cell volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and mean corpuscular volume was observed in group II, III and IV. Prosopis cineraria could restore the above in group treated with Parthenium at low dose level.
Pages: 294-296 | 468 Views 57 Downloads
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How to cite this article:
Anita Rathore, Rohitash Dadhich, Kamal Purohit, Shiv Kumar Sharma, Chandra Shekhar Vaishnava, Bincy Joseph, Anirudh Khatri. Impact of Prosopis cineraria (L.) Druce leaves on hematological parameters against induced sub-acute toxicity of Parthenium hysterophorus L. in wistar albino rats. Int J Chem Stud 2019;7(1):294-296.
