Vol. 7, Issue 2 (2019)
Evaluation of antidiabetic and antioxidant potential of custard apple (Annona squamosa) Leaf extracts: A compositional study
Author(s): Yashwant Kumar, Ajay Kumar Chandra, Shruti and HP Gajera
Abstract: Since time immemorial custard apple is closely associated with humans. In Indian subcontinents it is popularly known for their delicious fleshy fruit and lesser for its antioxidant and antidiabetic activities. Because of its higher nutritional value and unique nutraceutical properties, custard apple is widely cultivated throughout the world. In view of this the present investigation was undertaken to study the methanolic leaf extracts of global custard apple germplasms to identify the genotypes with its best combination as having significant amount of antioxidant and antidiabetic. The results showed that wide variability was present among custard apple genotypes for both α-amylase inhibition and DPPH radical scavenging activity. It also evidenced that the fruit width was negatively correlated with both antioxidant activity and antidiabetic activities. Further the study showed that smaller the fruit size evidenced higher the antidiabetic and antioxidant activities with elevated level of total phenolic acids. Finally, the study revealed that the methanolic extract of genotypes evidenced lowest IC50 value viz., Aml-11 (2.41 μg/mL) followed by Aml-12 (3.07 μg/mL) and Aml-4 (6.73 μg/mL) showing higher inhibition of PPA could be considered as candidate material for future ethnomedicinal research.
Pages: 889-895 | 367 Views 79 Downloads
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How to cite this article:
Yashwant Kumar, Ajay Kumar Chandra, Shruti, HP Gajera. Evaluation of antidiabetic and antioxidant potential of custard apple (Annona squamosa) Leaf extracts: A compositional study. Int J Chem Stud 2019;7(2):889-895.
