Vol. 7, Issue 2 (2019)
Comparative pharmacokinetics of Ofloxacin following single intravenous and oral administration in goat
Author(s): Himangshu Baruah, Dulal Chandra Roy, Rohini Kumar Roy, Jadav Sarma, Snigdha Hazarika and Sanjib Khargharia
Abstract: Pharmacokinetic (PK) behaviour of ofloxacin following single intravenous (iv) and oral administration in goat was evaluated. Ofloxacin was administered @ 5 mg/kg body weight by iv and oral route. Plasma concentration of ofloxacin at pre-scheduled times were processed and estimated by using HPLC. The PK parameters were determined by non-compartmental open model. The therapeutic concentration was achieved in 2.5 min and 45 min and maintained up to 36 h and 8 h following iv and oral administration respectively. The mean AUC, AUMC, t1/2, MRT, Cl and Vd are 58.94 ± 19.43 μg h/ml, 1539.57 ± 724.69 μg h2/ml, 15.58 ± 1.87 h, 22.46 ± 2.71 h, 135.60 ± 31.12 ml/h/kg and 2.85 ± 0.74 L/kg respectively following iv administration. The calculated AUC, AUMC, t1/2 ka, MRT after oral administration was 11.41 ± 1.13 m/h/ml, 221.11 ± 38.44 mg/h/ml, 5.404 ± 0.78 h, 16.04 ± 1.19 h. The kinetic behaviour following iv administration is suggestive of entero-hepatic recycling with a secondary peak at 24 h. Following oral administration, ofloxacin showed poor absorption and slow elimination with mean bioavailability of 24.14 ± 1.70 % and tmax of 5.16 ± 0.72 h.
Pages: 1375-1377 | 338 Views 45 Downloads
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How to cite this article:
Himangshu Baruah, Dulal Chandra Roy, Rohini Kumar Roy, Jadav Sarma, Snigdha Hazarika, Sanjib Khargharia. Comparative pharmacokinetics of Ofloxacin following single intravenous and oral administration in goat. Int J Chem Stud 2019;7(2):1375-1377.
