Vol. 7, Issue 2 (2019)
Cytokeratin 18: Skeletal protein of hepatocytes, its functions and diagnostic significance
Author(s): Sangamitra RKR, G Suganya, V Leela and M Balagangatharathilagar
Abstract: Liver, a complex organ performs various functions to maintain homeostasis in the body. The regenerative capacity of the liver is enormous and any injury to the liver can be detected only when 60-70 percent of the organ has been damaged. Injury to any organ can be detected by the use of biomarkers. Biomarkers are any biological molecule which acts as measurable indicators of biological process and one such biomarker for hepatic disease is Cytokeratin 18, an intermediate filament protein predominantly expressed in hepatocytes along with cytokeratin 8. Apart from maintaining the mechanical stability to cell structure, cytokeratin18 unveils highly dynamic features such as cell to cell signaling, progression of cell cycle, resistance to apoptosis, regulation of protein synthesis and hemostasis. This review explores the various studies related to functions mediated by cytokeratin 18 and its role as a potential biomarker for different pathological alterations in accordance with hepatic diseases.
Pages: 1504-1507 | 324 Views 50 Downloads
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How to cite this article:
Sangamitra RKR, G Suganya, V Leela, M Balagangatharathilagar. Cytokeratin 18: Skeletal protein of hepatocytes, its functions and diagnostic significance. Int J Chem Stud 2019;7(2):1504-1507.
