Vol. 7, Issue 2 (2019)
Neutrophil gelatinase associated lipocalins (NGAL) as an inflammatory biomarker: A special reference to renal system
Author(s): Ponnambiga T, V Leela, G Suganya, M Balagangathrathilagar and A Sivaprakasam
Abstract: Inflammation is a part of protective response of body to any harmful etiological agent. Inflammation is mainly characterized by local responses such as rubor, calor, dalor and functio- lechio. It is mediated by variety of cytokines and inflammatory warriors such as neutrophils, macrophage, and eosinophils at the site of injury. Apart from the mediators of inflammation, enhanced protein synthesis also occurs at the site of injury to combat the spread of infection. This newly synthesized protein molecule participates along with phagocytic warriors, mediates and resolutes inflammatory site. One of such inflammatory protein is NGAL, which belongs to lipocalin family, synthesized at site with various signaling cascade. Being part of inflammation, their levels also gets elevated in serum and urine, which rules out kidney injury, hence they exhibit a dual face of inflammatory mediator and biomarker of kidney disease (1). With this idea in the upcoming review we summarize the role of NGAL as a inflammatory mediator and its role in disease progression.
Pages: 1957-1963 | 331 Views 60 Downloads
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How to cite this article:
Ponnambiga T, V Leela, G Suganya, M Balagangathrathilagar, A Sivaprakasam. Neutrophil gelatinase associated lipocalins (NGAL) as an inflammatory biomarker: A special reference to renal system. Int J Chem Stud 2019;7(2):1957-1963.
