Vol. 7, Issue 5 (2019)
Effects on cardiopulmonary parameters of propofol, Ketofol and Etomidate as induction agent in glycopyrrolate premedicated dogs maintained under isoflurane anaesthesia
Author(s): Rahul Paul, Basanta Saikia, Hitesh Bayan, Bedanga Konwar, Analisha Debbarma and Chang L
Abstract: The present study was undertaken in 18 dogs with elective surgery (castration, spaying etc.) to evaluate the effect of propofol, ketofol and etomidate as induction agents in glycopyrrolate premedicated dogs maintained with isoflurane. The animals were randomly divided into three groups viz. group P, KP & E, comprising six animals in each group. All the animals of the three groups were premedicated with glycopyrrolate @ 0.01 mg/kg IM, 10 minutes prior induction. Propofol @ 6mg/kg IV, ketofol @ 4mg/kg and etomidate @ 3mg/kg was administered as induction agent in group P, KP and E respectively. Maintenance of anaesthesia was carried out by using isoflurane in all the animals. Cardiopulmonary parameters were studied at (baseline) 0 min and thereafter 5, 15, 30, and 60 minutes after induction. Heart rate significantly (P< 0.01) increased in all the groups compared to baseline at 5 min time interval and then gradually decreased towards the baseline. Respiration rate significantly (P< 0.01) decreased in group KP but non significantly in group P and E. Rectal temperature significantly (P< 0.01) decreased in group P and KP but non significantly decreased in group E. Significant (P< 0.05) decrease in SpO2 was observed in group P whereas significant (P< 0.01) decrease in SpO2 was observed in group KP and E followed by gradual increase in SpO2 in all three groups Non significant increase in ETCO2 followed by gradual decrease towards the baseline was observed in all three groups. Significant (P< 0.01) decrease in SP and DP was observed in group P whereas significant (P< 0.01) increase in SP and DP was observed in group KP. In group E non significant changes were observed in group E.
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How to cite this article:
Rahul Paul, Basanta Saikia, Hitesh Bayan, Bedanga Konwar, Analisha Debbarma, Chang L. Effects on cardiopulmonary parameters of propofol, Ketofol and Etomidate as induction agent in glycopyrrolate premedicated dogs maintained under isoflurane anaesthesia. Int J Chem Stud 2019;7(5):796-799.
