Vol. 7, Issue 5 (2019)
Drug release profile of malic acid-succinic acid-butane 1, 4-Diol Co-polyester
Author(s): Dr. Mohd. Amirul Islam
Abstract: Five samples (I-V) of malic acid-succinic acid-butane-1,4-diol co-polyesters were synthesized from five mixtures of malic acid and succinic acid in mole combinations (1.0+0.0), (0.9+0.1), (0.8+0.2), (0.7+0.3) and (0.6+0.4) respectively in each case with 1 mole of butane-1,4- diol following Dean-stark apparatus using FeCl3 (approximately 0.4% of the total weight) as catalyst. These co-polyesters were characterized by their molecular weights, IR-spectra, elemental analysis, hydrolytic degradation and swelling behavior in water and ethanol and solubility test in common organic solvents. The co-polyester-II had the highest molecular weight and it was selected for subsequent experiments. Its probable structure was assigned considering the hydroxyl and carboxyl groups of the monomers. Molecular weights were determined by end group analysis and viscosity method. At room temperature, the hydrolytic degradation study of the co-polyesters in solutions of different pH values showed that it remained intact in solutions of pH values 1.5-6.0, but gradually degraded in solutions of pH values >6.0. The co-polyester was investigated as an enteric coating material on diclofenac sodium core tablets. It was found that the coated tablet did not degrade or swell in the simulated gastric fluid (pH-1.2) for 2 hours. But it gradually degraded in the simulated intestinal fluid (pH-7.4) and within 45 minutes around 80% of diclofenac sodium released indicating the BP drug delivery profile. The toxicological test of the polymer is yet to be performed. If the polymer be proved to be non-toxic, it might be usable as an enteric coating material.
Pages: 2224-2228 | 244 Views 58 Downloads
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How to cite this article:
Dr. Mohd. Amirul Islam. Drug release profile of malic acid-succinic acid-butane 1, 4-Diol Co-polyester. Int J Chem Stud 2019;7(5):2224-2228.
