Vol. 7, Issue 6 (2019)
Determination of LD50 of aqueous extract of Anagallis arvensis in Wistar rats
Author(s): PA Chavan, GR Gangane, SD Moregaonkar, SR Rajurkar and GD Ranvir
Abstract: For the determination of LD50 of aqueous extract of Anagallis arvensis plant through oral route thirty Wistar rats were procured and divided into 5 groups (each contain 6 rats). Group I used as control group which was fed with ad- libitum normal feed and water. Single dose of aqueous extract of Anagallis arvensis was given orally @ 500, 1000, 2000 and 4000 mg/kg b.wt. to the rats of group IInd, IIIrd, IVth and Vth, respectively. The LD50 of aqueous extract of Anagallis arvensis plant through oral route was 1781.76 mg/kg b.wt. in Wistar rats. Histopathological examination of kidney showed focal to multifocal, moderate to severe congestion, occasional haemorrhagic cystic degeneration and necrotic changes. There was mild to moderate congestion, dilation of central vein and focal necrosis in parenchyma of liver.
Pages: 943-945 | 328 Views 79 Downloads
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How to cite this article:
PA Chavan, GR Gangane, SD Moregaonkar, SR Rajurkar, GD Ranvir. Determination of LD50 of aqueous extract of Anagallis arvensis in Wistar rats. Int J Chem Stud 2019;7(6):943-945.
