Vol. 7, Issue 6 (2019)
Hepatoprotective effect of Cassia fistula against carbon tetrachloride induced hepatotoxicity in wistar rats: Pathomorphological studies
Author(s): PM Ghadge, SR Rajurkar, ND Jadhav, GR Gangane and PB Kansatwad
Abstract: Experimental trial was conducted to evaluate hepatoprotective effects of Cassia fistula in carbon tetrachloride induced hepatotoxic wistar rats and its pathomorphological study for a period of 28 days. The study was conducted on 48 Wistar rats through six groups. Group I was taken healthy control. The group II, III, IV, V and VI being the treatment groups were given carbon tetrachloride for induction of hepatotoxicity for a period of 28 days. Group III treated with standard drug Silymarin and group IV, V and VI with different doses of aqueous extract of Cassia fistula. Toxicated rats show Behavioural changes, decrease in body weight and increase in relative organ weight. Gross and histopathological examination revealed mild to moderate changes in liver, kidney, lung, brain and testes in CCl4 treated rats. Daily dosing of aqueous extract of leaves of Cassia fistula showed ameliorative against CCl4 toxicated rats.
Pages: 1830-1834 | 255 Views 64 Downloads
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How to cite this article:
PM Ghadge, SR Rajurkar, ND Jadhav, GR Gangane, PB Kansatwad. Hepatoprotective effect of Cassia fistula against carbon tetrachloride induced hepatotoxicity in wistar rats: Pathomorphological studies. Int J Chem Stud 2019;7(6):1830-1834.
