Vol. 8, Issue 1 (2020)
Toxicological investigation of malic acid-succinic acid-butane 1, 4-diol co-polyester on albino rats
Author(s): Dr. Mohd. Amirul Islam and Dr. M Abu Bakr
Abstract: Malic Acid-Succinic Acid-Butane 1,4-diol Co-polyester(MSBC) is a biodegradable co-polyester synthesized from malic acid and succinic acid in different mole combinations with 1 mole of butane 1,4-diol following Dean-stark apparatus using FeCl3 (Approximately 0.4% of the total weight) as catalyst and o-xylene as the reaction medium at temperature 145-150 0C for about 7 hours. MSBC was administered intraperitoneally to albino rats at a dose of 300 mg rat-1day-1 for 21 consecutive days in order to assessing the toxic effect of MSBC. The studies included the gross observation such as changes in body weight, haematological profiles, biochemical parameter of blood and histopathology of liver, kidney, heart, lungs and spleen of control group, and experimental group of rats. The changes in body weight, haematological and biochemical parameters are statistically insignificant after administration of MSBC when compared to that of control group, and experimental group of rats. No abnormalities were found in the histopathology of the liver, kidney, heart, lung and spleen in the experimental group of rats when compared with control group of rats. This study preliminary infers that Malic Acid-Succinic Acid-Butane 1,4-diol Co-polyester is a safer biodegradable polymer expected to be usable as an enteric coating materials or other purposes where biodegradable polymers be needed to use safely.
DOI: 10.22271/chemi.2020.v8.i1o.8400
Pages: 1124-1130 | 533 Views 91 Downloads
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How to cite this article:
Dr. Mohd. Amirul Islam, Dr. M Abu Bakr. Toxicological investigation of malic acid-succinic acid-butane 1, 4-diol co-polyester on albino rats. Int J Chem Stud 2020;8(1):1124-1130. DOI: 10.22271/chemi.2020.v8.i1o.8400
