Vol. 8, Issue 3 (2020)
Clinico-physiological and haemato-biochemical evaluation of midazolam-ketofol anaesthesia in atropinized goats
Author(s): AS Sengar, SK Tiwari, Rukmani Dewangan and MS Maravi
Abstract: The study was conducted on six healthy non-descript goats of either sex weighing between 20-25 kg by administrating atropine sulphate (0.04 mg/kg I/M) followed by midazolam (0.4 mg/kg I/M) and 15 min. later followed by induction of anaesthesia with ketofol (5mg/kg I/V). Sedation with drooping of head after midazolam administration within 8.20±0.58 min. After ketofol administration went into lateral recumbency and onset of anaesthesia was 0.62±0.14 min. Corneal, palpebral and anal pinch reflexes were abolished completely. Complete relaxation of all muscles of jaw, tail, anus, prepuce, neck and limb was observed but for short duration. There was complete analgesia and moderated salivation after ketofol anaesthesia. The average duration of anaesthesia was 33.71±1.08 min. after which sign of recovery such as raising of head, tail flicking appeared and complete recovery took 62.14±1.53 min. after ketofol anaesthesia. There was no significant variations in rectal temperature whereas a significant (P<0.01) increase in heart rate was observed up to 30 min. There was significant (P<0.01) decrease in respiration rate up to 20 min. Non-significant decrease in Hb, PCV and TLC was observed. No significant changes in haemato-biochemical parameters except serum glucose level which increased significantly (P<0.01) after ketofol anaesthesia upto 60 min. All the parameters were within normal physiological range. Therefore, it can be concluded that midazolam-ketofol combination may be safely used as general anaesthesia in atropinized goats for short duration.
DOI: 10.22271/chemi.2020.v8.i3ah.9567
Pages: 2370-2374 | 425 Views 127 Downloads
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How to cite this article:
AS Sengar, SK Tiwari, Rukmani Dewangan, MS Maravi. Clinico-physiological and haemato-biochemical evaluation of midazolam-ketofol anaesthesia in atropinized goats. Int J Chem Stud 2020;8(3):2370-2374. DOI: 10.22271/chemi.2020.v8.i3ah.9567
